Preimplantation Genetic Testing (PGT)
Specialised embryo testing performed as part of IVF to screen for chromosomal abnormalities or specific inherited genetic conditions.
What is preimplantation genetic testing and who should consider it?
Preimplantation genetic testing (PGT) is a specialised technique performed as part of IVF, in which embryos are tested for chromosomal abnormalities or specific genetic conditions before being transferred to the uterus. A small number of cells is carefully biopsied from each embryo and analysed in a genetics laboratory. PGT can improve the chance of a successful embryo transfer and reduce the risk of miscarriage in selected patients.
What are the different types of PGT?
PGT-A (Preimplantation Genetic Testing for Aneuploidy) screens embryos for the correct number of chromosomes. Chromosomal abnormalities become more common with increasing maternal age and are a leading cause of failed implantation and miscarriage. PGT-M (for Monogenic Disorders) is used when one or both parents carry a known inherited genetic condition that could be passed on to a child. PGT-SR (for Structural Rearrangements) is used when a parent carries a chromosomal rearrangement such as a translocation. The appropriate type of testing is determined after careful discussion, often in consultation with a genetic counsellor.
Is PGT right for me?
PGT is not required for everyone undergoing IVF. It may be particularly beneficial for those with advanced maternal age, a history of recurrent miscarriage or failed IVF cycles, a known genetic condition in the family, or a partner carrying a chromosomal rearrangement. The decision to proceed with PGT is always made collaboratively, with a clear explanation of what the testing can and cannot tell us.
Ready to discuss your situation?
Book a consultation with Dr Kirshenbaum to explore your options.